The management of hyperglycemia is an important focus of treatment to achieve improved macrovascular and microvascular outcomes in patients with type 2 diabetes. Controlling blood-glucose levels often requires several strategies, including weight loss if needed, dietary control, increased physical activity, and antidiabetic medications.

Treatment regimens include single drugs and combinations of drugs from different classes. Choosing among the available medications requires consideration of benefits, adverse effects, mechanism of action, and cost


Type 2 Diabetes Medications Studied by Class With Abbreviations


ClassGeneric NameBrand Name
Biguanides Metformin (MET) Glucophage®, Glycomet
Second-generation sulfonylureas (SU) Glimepiride Amaryl®,Glimisave,GP
Glipizide Glynase,Dibizide
Glyburide Daonil,Euglucon,Glinil
Meglitinides (MEG) Repaglinide (Rep) Prandin®
Nateglinide Starlix®
Thiazolidinediones (TZD) Pioglitazone (Pio) Pioz®
Rosiglitazone (RSG) Avandia®
Dipeptidyl peptidase-4 (DPP-4) inhibitors Sitagliptin Januvia®
Saxagliptin Onglyza®
Glucagon-like peptide-1 (GLP-1) receptor agonists Exenatide injection Byetta®
Liraglutide injection Victoza®
Insulin NPH insulin Humulin N®, Novolin N®
Insulin detemir Levemir®
Insulin glargine Lantus®
70% NPH: 30% Regular Humulin® 70/30, Novolin® 70/30
50% lispro protamine suspension: 50% lispro Humalog® Mix50/50™
75% lispro protamine suspension: 25% lispro Humalog® Mix75/25™
70% aspart protamine suspension: 30% aspart Novomix® Mix 70/30


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